However, even before completing his PhD, Professor Lam was offered a position as a virologist at the new Faculty of Medicine at University of Malaya in 1966.
In subsequent years, Professor Lam developed new tools for diagnosing viral infections, an accomplishment that led to the designation of the Faculty of Medicine at the University of Malaya as a WHO National Center for Rapid Viral Diagnosis in 1980.
Actively engaged in the WHO Programme on Emerging Infectious Diseases (EID) since 1990, Professor Lam's team made key discoveries, including identifying viruses causing fatal encephalitis and outbreaks of hand, foot and mouth disease. They also uncovered the cause of polyarthritis in Malaysia (chikungunya virus) and a Hantavirus-like infection associated with renal diseases.