In 1999, she founded the College of Pathologists under the Academy of Medicine Malaysia, uniting the pathology profession. Professor Looi's advocacy for legislative improvements in pathology practices culminated in the Pathology Laboratory Act 2007 and the establishment of the National Accreditation Scheme for Pathology Laboratories.
Her efforts extended to international collaborations, scientific workshops, and projects promoting scientific writing and research methodology. Professor Looi's leadership roles in prestigious organisations, such as the World Association of Societies of Pathology and Laboratory Medicine, reflect her global impact.
Acknowledging her exceptional contributions, Professor Looi received the inaugural Profesor Ulung Negara (National Distinguished Professor) title in 2010, becoming the first medical scientist and woman to receive this honor.
International accolades, including the Distinguished Fellow of the Royal College of Pathologists of Australasia, ASEAN Outstanding Scientist and Technologist Award, and Gold-Headed Cane from the World Association of Societies of Pathology and Laboratory Medicine, showcase her global recognition.